Virtual and biophysical screening targeting the γ-tubulin complex--a new target for the inhibition of microtubule nucleation.

Microtubules are the main constituents of mitotic spindles. They are nucleated in large amounts during spindle assembly, from multiprotein complexes containing γ-tubulin and associated γ-tubulin complex proteins (GCPs). With the aim of developing anti-cancer drugs targeting these nucleating complexe...

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Autores principales: Olivier Cala, Marie-Hélène Remy, Valérie Guillet, Andreas Merdes, Lionel Mourey, Alain Milon, Georges Czaplicki
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/75705f809df6439785004efd0ffb3743
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