Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.

In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories depend on genomic features by comparing the adaptation in three...

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Autores principales:	Marco Fumasoni, Andrew W Murray
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/758b26a78ec04da9b0298c1bdc690338
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spelling	oai:doaj.org-article:758b26a78ec04da9b0298c1bdc6903382021-12-02T20:03:15ZPloidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.1553-73901553-740410.1371/journal.pgen.1009875https://doaj.org/article/758b26a78ec04da9b0298c1bdc6903382021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009875https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories depend on genomic features by comparing the adaptation in three strains: haploids, diploids, and recombination deficient haploids. In all three, adaptation happens within 1000 generations at rates that are correlated with the initial fitness defect of the ancestors. Mutations in individual genes are selected at different frequencies in populations with different genomic features, but the benefits these mutations confer are similar in the three strains, and combinations of these mutations reproduce the fitness gains of evolved populations. Despite the differences in the selected mutations, adaptation targets the same three functional modules in strains with different genomic features, revealing a common evolutionary response to constitutive DNA replication stress.Marco FumasoniAndrew W MurrayPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 11, p e1009875 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Marco Fumasoni Andrew W Murray Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.
description	In haploid budding yeast, evolutionary adaptation to constitutive DNA replication stress alters three genome maintenance modules: DNA replication, the DNA damage checkpoint, and sister chromatid cohesion. We asked how these trajectories depend on genomic features by comparing the adaptation in three strains: haploids, diploids, and recombination deficient haploids. In all three, adaptation happens within 1000 generations at rates that are correlated with the initial fitness defect of the ancestors. Mutations in individual genes are selected at different frequencies in populations with different genomic features, but the benefits these mutations confer are similar in the three strains, and combinations of these mutations reproduce the fitness gains of evolved populations. Despite the differences in the selected mutations, adaptation targets the same three functional modules in strains with different genomic features, revealing a common evolutionary response to constitutive DNA replication stress.
format	article
author	Marco Fumasoni Andrew W Murray
author_facet	Marco Fumasoni Andrew W Murray
author_sort	Marco Fumasoni
title	Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.
title_short	Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.
title_full	Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.
title_fullStr	Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.
title_full_unstemmed	Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.
title_sort	ploidy and recombination proficiency shape the evolutionary adaptation to constitutive dna replication stress.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/758b26a78ec04da9b0298c1bdc690338
work_keys_str_mv	AT marcofumasoni ploidyandrecombinationproficiencyshapetheevolutionaryadaptationtoconstitutivednareplicationstress AT andrewwmurray ploidyandrecombinationproficiencyshapetheevolutionaryadaptationtoconstitutivednareplicationstress
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Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.

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