Eμ and 3′RR IgH enhancers show hierarchic unilateral dependence in mature B-cells

Abstract Enhancer and super-enhancers are master regulators of cell fate. While they act at long-distances on adjacent genes, it is unclear whether they also act on one another. The immunoglobulin heavy chain (IgH) locus is unique in carrying two super-enhancers at both ends of the constant gene clu...

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Autores principales: A. Saintamand, C. Vincent-Fabert, M. Marquet, N. Ghazzaui, V. Magnone, E. Pinaud, M. Cogné, Y. Denizot
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/759dce4b4ff54191badca142fafe61e7
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