Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

Abstract We have redesigned probes for in situ proximity ligation assay (PLA), resulting in more efficient localized detection of target proteins. In situ PLA depends on recognition of target proteins by pairs of antibody-oligonucleotide conjugates (PLA probes), which jointly give rise to DNA circle...

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Main Authors: Axel Klaesson, Karin Grannas, Tonge Ebai, Johan Heldin, Björn Koos, Mattias Leino, Doroteya Raykova, Johan Oelrich, Linda Arngården, Ola Söderberg, Ulf Landegren
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/75ad5875c3544fa48fd0da457da9bb4f
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