CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

Activated B cells differentiate into antibody-producing plasma cells in the germinal centre in secondary lymphoid organs. Here the authors show that this differentiation process and related transcription programs are modulated by the transcription factor CTCF, partly by suppressing the premature exp...

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Autores principales:	Arantxa Pérez-García, Ester Marina-Zárate, Ángel F. Álvarez-Prado, Jose M. Ligos, Niels Galjart, Almudena R. Ramiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/75b203f03cb5452fbe3bed7da17951d3
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spelling	oai:doaj.org-article:75b203f03cb5452fbe3bed7da17951d32021-12-02T17:06:22ZCTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation10.1038/ncomms160672041-1723https://doaj.org/article/75b203f03cb5452fbe3bed7da17951d32017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16067https://doaj.org/toc/2041-1723Activated B cells differentiate into antibody-producing plasma cells in the germinal centre in secondary lymphoid organs. Here the authors show that this differentiation process and related transcription programs are modulated by the transcription factor CTCF, partly by suppressing the premature expression of Blimp-1.Arantxa Pérez-GarcíaEster Marina-ZárateÁngel F. Álvarez-PradoJose M. LigosNiels GaljartAlmudena R. RamiroNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arantxa Pérez-García Ester Marina-Zárate Ángel F. Álvarez-Prado Jose M. Ligos Niels Galjart Almudena R. Ramiro CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation
description	Activated B cells differentiate into antibody-producing plasma cells in the germinal centre in secondary lymphoid organs. Here the authors show that this differentiation process and related transcription programs are modulated by the transcription factor CTCF, partly by suppressing the premature expression of Blimp-1.
format	article
author	Arantxa Pérez-García Ester Marina-Zárate Ángel F. Álvarez-Prado Jose M. Ligos Niels Galjart Almudena R. Ramiro
author_facet	Arantxa Pérez-García Ester Marina-Zárate Ángel F. Álvarez-Prado Jose M. Ligos Niels Galjart Almudena R. Ramiro
author_sort	Arantxa Pérez-García
title	CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation
title_short	CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation
title_full	CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation
title_fullStr	CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation
title_full_unstemmed	CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation
title_sort	ctcf orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/75b203f03cb5452fbe3bed7da17951d3
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CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

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