Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

ARID1A, which is often mutated in human endometrial cancer, is a component of the SWI/SNF chromatin remodelling complex. Here, the authors show that Arid1a mutations in the mouse endometrium and primary human endometrial epithelial cells cause widespread reprogramming of gene transcription and resul...

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Autores principales:	Yohan Suryo Rahmanto, Wenjing Shen, Xu Shi, Xi Chen, Yu Yu, Zheng-Cheng Yu, Tsutomu Miyamoto, Meng-Horng Lee, Vivek Singh, Ryoichi Asaka, Geoffrey Shimberg, Michele I. Vitolo, Stuart S. Martin, Denis Wirtz, Ronny Drapkin, Jianhua Xuan, Tian-Li Wang, Ie-Ming Shih
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/75bea59380ee4facabb9a13db669ea7a
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spelling	oai:doaj.org-article:75bea59380ee4facabb9a13db669ea7a2021-12-02T17:51:19ZInactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming10.1038/s41467-020-16416-02041-1723https://doaj.org/article/75bea59380ee4facabb9a13db669ea7a2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16416-0https://doaj.org/toc/2041-1723ARID1A, which is often mutated in human endometrial cancer, is a component of the SWI/SNF chromatin remodelling complex. Here, the authors show that Arid1a mutations in the mouse endometrium and primary human endometrial epithelial cells cause widespread reprogramming of gene transcription and result in a loss of response to TGFβ.Yohan Suryo RahmantoWenjing ShenXu ShiXi ChenYu YuZheng-Cheng YuTsutomu MiyamotoMeng-Horng LeeVivek SinghRyoichi AsakaGeoffrey ShimbergMichele I. VitoloStuart S. MartinDenis WirtzRonny DrapkinJianhua XuanTian-Li WangIe-Ming ShihNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yohan Suryo Rahmanto Wenjing Shen Xu Shi Xi Chen Yu Yu Zheng-Cheng Yu Tsutomu Miyamoto Meng-Horng Lee Vivek Singh Ryoichi Asaka Geoffrey Shimberg Michele I. Vitolo Stuart S. Martin Denis Wirtz Ronny Drapkin Jianhua Xuan Tian-Li Wang Ie-Ming Shih Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
description	ARID1A, which is often mutated in human endometrial cancer, is a component of the SWI/SNF chromatin remodelling complex. Here, the authors show that Arid1a mutations in the mouse endometrium and primary human endometrial epithelial cells cause widespread reprogramming of gene transcription and result in a loss of response to TGFβ.
format	article
author	Yohan Suryo Rahmanto Wenjing Shen Xu Shi Xi Chen Yu Yu Zheng-Cheng Yu Tsutomu Miyamoto Meng-Horng Lee Vivek Singh Ryoichi Asaka Geoffrey Shimberg Michele I. Vitolo Stuart S. Martin Denis Wirtz Ronny Drapkin Jianhua Xuan Tian-Li Wang Ie-Ming Shih
author_facet	Yohan Suryo Rahmanto Wenjing Shen Xu Shi Xi Chen Yu Yu Zheng-Cheng Yu Tsutomu Miyamoto Meng-Horng Lee Vivek Singh Ryoichi Asaka Geoffrey Shimberg Michele I. Vitolo Stuart S. Martin Denis Wirtz Ronny Drapkin Jianhua Xuan Tian-Li Wang Ie-Ming Shih
author_sort	Yohan Suryo Rahmanto
title	Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
title_short	Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
title_full	Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
title_fullStr	Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
title_full_unstemmed	Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
title_sort	inactivation of arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/75bea59380ee4facabb9a13db669ea7a
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Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming

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