Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
Rheumatoid arthritis patients respond differently to anti-TNF treatment. Using community-based challenge, the authors show that currently available data does not reveal meaningful genetic predictors of response to anti-TNF therapy, thus confirming clinical observations.
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Nature Portfolio
2016
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oai:doaj.org-article:75f77ca55d0d4c649c320c5fdaffe2932021-12-02T17:32:04ZCrowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis10.1038/ncomms124602041-1723https://doaj.org/article/75f77ca55d0d4c649c320c5fdaffe2932016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12460https://doaj.org/toc/2041-1723Rheumatoid arthritis patients respond differently to anti-TNF treatment. Using community-based challenge, the authors show that currently available data does not reveal meaningful genetic predictors of response to anti-TNF therapy, thus confirming clinical observations.Solveig K. SiebertsFan ZhuJavier García-GarcíaEli StahlAbhishek PratapGaurav PandeyDimitrios PappasDaniel AguilarBernat AntonJaume BonetRidvan EksiOriol FornésEmre GuneyHongdong LiManuel Alejandro MarínBharat PanwarJoan Planas-IglesiasDaniel PoglayenJing CuiAndre O. FalcaoChristine SuverBruce HoffVenkat S. K. BalagurusamyDonna DillenbergerElias Chaibub NetoThea NormanTero AittokallioMuhammad Ammad-ud-dinChloe-Agathe AzencottVíctor BellónValentina BoevaKerstin BunteHimanshu ChhedaLu ChengJukka CoranderMichel DumontierAnna GoldenbergPeddinti GopalacharyuluMohsen HajilooDaniel HidruAlok JaiswalSamuel KaskiBeyrem KhalfaouiSuleiman Ali KhanEric R. KramerPekka MarttinenAziz M. MezliniBhuvan MolpariaMatti PirinenJanna SaarelaMatthias SamwaldVéronique StovenHao TangJing TangAli TorkamaniJean-Phillipe VertBo WangTao WangKrister WennerbergNathan E. WineingerGuanghua XiaoYang XieRae YeungXiaowei ZhanCheng ZhaoMembers of the Rheumatoid Arthritis Challenge ConsortiumJeff GreenbergJoel KremerKaleb MichaudAnne BartonMarieke CoenenXavier MarietteCorinne MiceliNancy ShadickMichael WeinblattNiek de VriesPaul P. TakDanielle GerlagTom W. J. HuizingaFina KurreemanCornelia F. AllaartS. Louis Bridges Jr.Lindsey CriswellLarry MorelandLars KlareskogSaedis SaevarsdottirLeonid PadyukovPeter K. GregersenStephen FriendRobert PlengeGustavo StolovitzkyBaldo OlivaYuanfang GuanLara M. MangraviteNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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Science Q Solveig K. Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O. Falcao Christine Suver Bruce Hoff Venkat S. K. Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-ud-din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R. Kramer Pekka Marttinen Aziz M. Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E. Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Members of the Rheumatoid Arthritis Challenge Consortium Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P. Tak Danielle Gerlag Tom W. J. Huizinga Fina Kurreeman Cornelia F. Allaart S. Louis Bridges Jr. Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K. Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M. Mangravite Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis |
| description |
Rheumatoid arthritis patients respond differently to anti-TNF treatment. Using community-based challenge, the authors show that currently available data does not reveal meaningful genetic predictors of response to anti-TNF therapy, thus confirming clinical observations. |
| format |
article |
| author |
Solveig K. Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O. Falcao Christine Suver Bruce Hoff Venkat S. K. Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-ud-din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R. Kramer Pekka Marttinen Aziz M. Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E. Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Members of the Rheumatoid Arthritis Challenge Consortium Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P. Tak Danielle Gerlag Tom W. J. Huizinga Fina Kurreeman Cornelia F. Allaart S. Louis Bridges Jr. Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K. Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M. Mangravite |
| author_facet |
Solveig K. Sieberts Fan Zhu Javier García-García Eli Stahl Abhishek Pratap Gaurav Pandey Dimitrios Pappas Daniel Aguilar Bernat Anton Jaume Bonet Ridvan Eksi Oriol Fornés Emre Guney Hongdong Li Manuel Alejandro Marín Bharat Panwar Joan Planas-Iglesias Daniel Poglayen Jing Cui Andre O. Falcao Christine Suver Bruce Hoff Venkat S. K. Balagurusamy Donna Dillenberger Elias Chaibub Neto Thea Norman Tero Aittokallio Muhammad Ammad-ud-din Chloe-Agathe Azencott Víctor Bellón Valentina Boeva Kerstin Bunte Himanshu Chheda Lu Cheng Jukka Corander Michel Dumontier Anna Goldenberg Peddinti Gopalacharyulu Mohsen Hajiloo Daniel Hidru Alok Jaiswal Samuel Kaski Beyrem Khalfaoui Suleiman Ali Khan Eric R. Kramer Pekka Marttinen Aziz M. Mezlini Bhuvan Molparia Matti Pirinen Janna Saarela Matthias Samwald Véronique Stoven Hao Tang Jing Tang Ali Torkamani Jean-Phillipe Vert Bo Wang Tao Wang Krister Wennerberg Nathan E. Wineinger Guanghua Xiao Yang Xie Rae Yeung Xiaowei Zhan Cheng Zhao Members of the Rheumatoid Arthritis Challenge Consortium Jeff Greenberg Joel Kremer Kaleb Michaud Anne Barton Marieke Coenen Xavier Mariette Corinne Miceli Nancy Shadick Michael Weinblatt Niek de Vries Paul P. Tak Danielle Gerlag Tom W. J. Huizinga Fina Kurreeman Cornelia F. Allaart S. Louis Bridges Jr. Lindsey Criswell Larry Moreland Lars Klareskog Saedis Saevarsdottir Leonid Padyukov Peter K. Gregersen Stephen Friend Robert Plenge Gustavo Stolovitzky Baldo Oliva Yuanfang Guan Lara M. Mangravite |
| author_sort |
Solveig K. Sieberts |
| title |
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis |
| title_short |
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis |
| title_full |
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis |
| title_fullStr |
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis |
| title_full_unstemmed |
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis |
| title_sort |
crowdsourced assessment of common genetic contribution to predicting anti-tnf treatment response in rheumatoid arthritis |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/75f77ca55d0d4c649c320c5fdaffe293 |
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