Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences

Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The...

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Main Authors:	Tao Fan, Chunxiang Li, Jie He
Format:	article
Language:	EN
Published:	BMC 2021
Subjects:	Lung adenocarcinoma Sex differences Tumor microenvironment ESTIMATE algorithm Tumor-infiltrating immune cells Medicine R Physiology QP1-981
Online Access:	https://doaj.org/article/76445aac66e94e7e853dd867bbb07baf
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spelling	oai:doaj.org-article:76445aac66e94e7e853dd867bbb07baf2021-12-05T12:04:08ZPrognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences10.1186/s13293-021-00406-y2042-6410https://doaj.org/article/76445aac66e94e7e853dd867bbb07baf2021-12-01T00:00:00Zhttps://doi.org/10.1186/s13293-021-00406-yhttps://doaj.org/toc/2042-6410Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The density of memory B cells in TME of female patients with LUAD was significantly higher than that of male patients, which may explain that female patients with LUAD have a better prognosis than that of male patients. 4. We identified immune-related genes that predicted the prognosis of female and male LUAD patients, respectively, and their predictive value were verified by another independent cohort.Tao FanChunxiang LiJie HeBMCarticleLung adenocarcinomaSex differencesTumor microenvironmentESTIMATE algorithmTumor-infiltrating immune cellsMedicineRPhysiologyQP1-981ENBiology of Sex Differences, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lung adenocarcinoma Sex differences Tumor microenvironment ESTIMATE algorithm Tumor-infiltrating immune cells Medicine R Physiology QP1-981
spellingShingle	Lung adenocarcinoma Sex differences Tumor microenvironment ESTIMATE algorithm Tumor-infiltrating immune cells Medicine R Physiology QP1-981 Tao Fan Chunxiang Li Jie He Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
description	Highlights 1. We presented a detailed and comprehensive analysis of immune cell infiltration in tumor microenvironment (TME) of female and male patients with lung adenocarcinoma (LUAD). 2. We compared the differences in the tumor immune microenvironment between female and male LUAD patients. 3. The density of memory B cells in TME of female patients with LUAD was significantly higher than that of male patients, which may explain that female patients with LUAD have a better prognosis than that of male patients. 4. We identified immune-related genes that predicted the prognosis of female and male LUAD patients, respectively, and their predictive value were verified by another independent cohort.
format	article
author	Tao Fan Chunxiang Li Jie He
author_facet	Tao Fan Chunxiang Li Jie He
author_sort	Tao Fan
title	Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_short	Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_full	Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_fullStr	Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_full_unstemmed	Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
title_sort	prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences
publisher	BMC
publishDate	2021
url	https://doaj.org/article/76445aac66e94e7e853dd867bbb07baf
work_keys_str_mv	AT taofan prognosticvalueofimmunerelatedgenesandcomparativeanalysisofimmunecellinfiltrationinlungadenocarcinomasexdifferences AT chunxiangli prognosticvalueofimmunerelatedgenesandcomparativeanalysisofimmunecellinfiltrationinlungadenocarcinomasexdifferences AT jiehe prognosticvalueofimmunerelatedgenesandcomparativeanalysisofimmunecellinfiltrationinlungadenocarcinomasexdifferences
_version_	1718372262367723520

Prognostic value of immune-related genes and comparative analysis of immune cell infiltration in lung adenocarcinoma: sex differences

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