Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines

Little is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in harmaline and oxidative deamination of amines.

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Autores principales: Toshiki Nagakubo, Takuto Kumano, Takehiro Ohta, Yoshiteru Hashimoto, Michihiko Kobayashi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/765881ec59a145a2b90cd6c617ec662b
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