Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines

Little is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in harmaline and oxidative deamination of amines.

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Autores principales:	Toshiki Nagakubo, Takuto Kumano, Takehiro Ohta, Yoshiteru Hashimoto, Michihiko Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/765881ec59a145a2b90cd6c617ec662b
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spelling	oai:doaj.org-article:765881ec59a145a2b90cd6c617ec662b2021-12-02T15:35:11ZCopper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines10.1038/s41467-018-08280-w2041-1723https://doaj.org/article/765881ec59a145a2b90cd6c617ec662b2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08280-whttps://doaj.org/toc/2041-1723Little is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in harmaline and oxidative deamination of amines.Toshiki NagakuboTakuto KumanoTakehiro OhtaYoshiteru HashimotoMichihiko KobayashiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Toshiki Nagakubo Takuto Kumano Takehiro Ohta Yoshiteru Hashimoto Michihiko Kobayashi Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
description	Little is known about the degradation pathway of cyclic imines that are frequently found in bioactive secondary metabolites. Here, the authors found and characterised a copper amine oxidase, HarA that catalyses a ring-opening reaction of cyclic imine in harmaline and oxidative deamination of amines.
format	article
author	Toshiki Nagakubo Takuto Kumano Takehiro Ohta Yoshiteru Hashimoto Michihiko Kobayashi
author_facet	Toshiki Nagakubo Takuto Kumano Takehiro Ohta Yoshiteru Hashimoto Michihiko Kobayashi
author_sort	Toshiki Nagakubo
title	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_short	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_full	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_fullStr	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_full_unstemmed	Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
title_sort	copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/765881ec59a145a2b90cd6c617ec662b
work_keys_str_mv	AT toshikinagakubo copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines AT takutokumano copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines AT takehiroohta copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines AT yoshiteruhashimoto copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines AT michihikokobayashi copperamineoxidasescatalyzetheoxidativedeaminationandhydrolysisofcyclicimines
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Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines

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