Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells

Simultaneous quantification of DNA, RNA and protein at the single cell level has not yet been possible. Here the authors introduce a molecular labelling and detection strategy to quantify synthesis of these biomolecules and couple it to transient cell states through parallel quantification of state-...

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Main Authors:	Samuel C. Kimmey, Luciene Borges, Reema Baskar, Sean C. Bendall
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/767c29a6bd7f4d73a67d7b29da9a2d79
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id	oai:doaj.org-article:767c29a6bd7f4d73a67d7b29da9a2d79
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spelling	oai:doaj.org-article:767c29a6bd7f4d73a67d7b29da9a2d792021-12-02T14:40:18ZParallel analysis of tri-molecular biosynthesis with cell identity and function in single cells10.1038/s41467-019-09128-72041-1723https://doaj.org/article/767c29a6bd7f4d73a67d7b29da9a2d792019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09128-7https://doaj.org/toc/2041-1723Simultaneous quantification of DNA, RNA and protein at the single cell level has not yet been possible. Here the authors introduce a molecular labelling and detection strategy to quantify synthesis of these biomolecules and couple it to transient cell states through parallel quantification of state-dependent biomolecules.Samuel C. KimmeyLuciene BorgesReema BaskarSean C. BendallNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel C. Kimmey Luciene Borges Reema Baskar Sean C. Bendall Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells
description	Simultaneous quantification of DNA, RNA and protein at the single cell level has not yet been possible. Here the authors introduce a molecular labelling and detection strategy to quantify synthesis of these biomolecules and couple it to transient cell states through parallel quantification of state-dependent biomolecules.
format	article
author	Samuel C. Kimmey Luciene Borges Reema Baskar Sean C. Bendall
author_facet	Samuel C. Kimmey Luciene Borges Reema Baskar Sean C. Bendall
author_sort	Samuel C. Kimmey
title	Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells
title_short	Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells
title_full	Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells
title_fullStr	Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells
title_full_unstemmed	Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells
title_sort	parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/767c29a6bd7f4d73a67d7b29da9a2d79
work_keys_str_mv	AT samuelckimmey parallelanalysisoftrimolecularbiosynthesiswithcellidentityandfunctioninsinglecells AT lucieneborges parallelanalysisoftrimolecularbiosynthesiswithcellidentityandfunctioninsinglecells AT reemabaskar parallelanalysisoftrimolecularbiosynthesiswithcellidentityandfunctioninsinglecells AT seancbendall parallelanalysisoftrimolecularbiosynthesiswithcellidentityandfunctioninsinglecells
_version_	1718390363005124608

Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells

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