Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules

The adaptor protein zyxin is known for its mechanosensing function in the maintenance of actin network. Here the authors show that zyxin is key to blood homeostasis and thrombosis by controlling the endothelial release of von Willebrand factor and the formation of actin scaffolds on exocytic granule...

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Bibliographic Details
Main Authors: Xiaofan Han, Pin Li, Zhenghao Yang, Xiaoshuai Huang, Guoqin Wei, Yujie Sun, Xuya Kang, Xueting Hu, Qiuping Deng, Liangyi Chen, Aibin He, Yingqing Huo, Dong Li, Eric Betzig, Jincai Luo
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/76945a8838754779baa5979b1b9c124a
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