Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules

The adaptor protein zyxin is known for its mechanosensing function in the maintenance of actin network. Here the authors show that zyxin is key to blood homeostasis and thrombosis by controlling the endothelial release of von Willebrand factor and the formation of actin scaffolds on exocytic granule...

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Autores principales:	Xiaofan Han, Pin Li, Zhenghao Yang, Xiaoshuai Huang, Guoqin Wei, Yujie Sun, Xuya Kang, Xueting Hu, Qiuping Deng, Liangyi Chen, Aibin He, Yingqing Huo, Dong Li, Eric Betzig, Jincai Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76945a8838754779baa5979b1b9c124a
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spelling	oai:doaj.org-article:76945a8838754779baa5979b1b9c124a2021-12-02T14:40:56ZZyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules10.1038/ncomms146392041-1723https://doaj.org/article/76945a8838754779baa5979b1b9c124a2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14639https://doaj.org/toc/2041-1723The adaptor protein zyxin is known for its mechanosensing function in the maintenance of actin network. Here the authors show that zyxin is key to blood homeostasis and thrombosis by controlling the endothelial release of von Willebrand factor and the formation of actin scaffolds on exocytic granules.Xiaofan HanPin LiZhenghao YangXiaoshuai HuangGuoqin WeiYujie SunXuya KangXueting HuQiuping DengLiangyi ChenAibin HeYingqing HuoDong LiEric BetzigJincai LuoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaofan Han Pin Li Zhenghao Yang Xiaoshuai Huang Guoqin Wei Yujie Sun Xuya Kang Xueting Hu Qiuping Deng Liangyi Chen Aibin He Yingqing Huo Dong Li Eric Betzig Jincai Luo Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
description	The adaptor protein zyxin is known for its mechanosensing function in the maintenance of actin network. Here the authors show that zyxin is key to blood homeostasis and thrombosis by controlling the endothelial release of von Willebrand factor and the formation of actin scaffolds on exocytic granules.
format	article
author	Xiaofan Han Pin Li Zhenghao Yang Xiaoshuai Huang Guoqin Wei Yujie Sun Xuya Kang Xueting Hu Qiuping Deng Liangyi Chen Aibin He Yingqing Huo Dong Li Eric Betzig Jincai Luo
author_facet	Xiaofan Han Pin Li Zhenghao Yang Xiaoshuai Huang Guoqin Wei Yujie Sun Xuya Kang Xueting Hu Qiuping Deng Liangyi Chen Aibin He Yingqing Huo Dong Li Eric Betzig Jincai Luo
author_sort	Xiaofan Han
title	Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
title_short	Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
title_full	Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
title_fullStr	Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
title_full_unstemmed	Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
title_sort	zyxin regulates endothelial von willebrand factor secretion by reorganizing actin filaments around exocytic granules
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/76945a8838754779baa5979b1b9c124a
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Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules

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