The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice

The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice

Beta-cell function is often impaired in obesity through incompletely understood mechanisms. Here the authors show that the long noncoding RNA βFaar is reduced by diet-induced obesity in mice, which leads to impaired beta-cell function via miR-138-5p and survival via TRAF3 Interacting Protein 2.

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Autores principales: Fangfang Zhang, Yue Yang, Xi Chen, Yue Liu, Qianxing Hu, Bin Huang, Yuhong Liu, Yi Pan, Yanfeng Zhang, Dechen Liu, Rui Liang, Guoqing Li, Qiong Wei, Ling Li, Liang Jin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/76b0f47910f843d79f36da1d4832791e
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https://doaj.org/article/76b0f47910f843d79f36da1d4832791e

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