The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice

Beta-cell function is often impaired in obesity through incompletely understood mechanisms. Here the authors show that the long noncoding RNA βFaar is reduced by diet-induced obesity in mice, which leads to impaired beta-cell function via miR-138-5p and survival via TRAF3 Interacting Protein 2.

Guardado en:

Detalles Bibliográficos
Autores principales:	Fangfang Zhang, Yue Yang, Xi Chen, Yue Liu, Qianxing Hu, Bin Huang, Yuhong Liu, Yi Pan, Yanfeng Zhang, Dechen Liu, Rui Liang, Guoqing Li, Qiong Wei, Ling Li, Liang Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/76b0f47910f843d79f36da1d4832791e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:76b0f47910f843d79f36da1d4832791e
record_format	dspace
spelling	oai:doaj.org-article:76b0f47910f843d79f36da1d4832791e2021-12-02T16:31:58ZThe long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice10.1038/s41467-021-24302-62041-1723https://doaj.org/article/76b0f47910f843d79f36da1d4832791e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24302-6https://doaj.org/toc/2041-1723Beta-cell function is often impaired in obesity through incompletely understood mechanisms. Here the authors show that the long noncoding RNA βFaar is reduced by diet-induced obesity in mice, which leads to impaired beta-cell function via miR-138-5p and survival via TRAF3 Interacting Protein 2.Fangfang ZhangYue YangXi ChenYue LiuQianxing HuBin HuangYuhong LiuYi PanYanfeng ZhangDechen LiuRui LiangGuoqing LiQiong WeiLing LiLiang JinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fangfang Zhang Yue Yang Xi Chen Yue Liu Qianxing Hu Bin Huang Yuhong Liu Yi Pan Yanfeng Zhang Dechen Liu Rui Liang Guoqing Li Qiong Wei Ling Li Liang Jin The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
description	Beta-cell function is often impaired in obesity through incompletely understood mechanisms. Here the authors show that the long noncoding RNA βFaar is reduced by diet-induced obesity in mice, which leads to impaired beta-cell function via miR-138-5p and survival via TRAF3 Interacting Protein 2.
format	article
author	Fangfang Zhang Yue Yang Xi Chen Yue Liu Qianxing Hu Bin Huang Yuhong Liu Yi Pan Yanfeng Zhang Dechen Liu Rui Liang Guoqing Li Qiong Wei Ling Li Liang Jin
author_facet	Fangfang Zhang Yue Yang Xi Chen Yue Liu Qianxing Hu Bin Huang Yuhong Liu Yi Pan Yanfeng Zhang Dechen Liu Rui Liang Guoqing Li Qiong Wei Ling Li Liang Jin
author_sort	Fangfang Zhang
title	The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
title_short	The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
title_full	The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
title_fullStr	The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
title_full_unstemmed	The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
title_sort	long non-coding rna βfaar regulates islet β-cell function and survival during obesity in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/76b0f47910f843d79f36da1d4832791e
work_keys_str_mv	AT fangfangzhang thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yueyang thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT xichen thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yueliu thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT qianxinghu thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT binhuang thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yuhongliu thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yipan thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yanfengzhang thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT dechenliu thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT ruiliang thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT guoqingli thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT qiongwei thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT lingli thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT liangjin thelongnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT fangfangzhang longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yueyang longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT xichen longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yueliu longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT qianxinghu longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT binhuang longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yuhongliu longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yipan longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT yanfengzhang longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT dechenliu longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT ruiliang longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT guoqingli longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT qiongwei longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT lingli longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice AT liangjin longnoncodingrnabfaarregulatesisletbcellfunctionandsurvivalduringobesityinmice
_version_	1718383816740962304

The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice

Ejemplares similares