Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes

Panea et al showed that epithelia-specific butyrophilinlike 2 (Btnl2) suppressed homeostatic proliferation of γδ intraepithelial lymphocytes (IELs) preferentially in the ileum and used high throughput transcriptomic characterization of Btnl2-deficient γδ IELs to demonstrate that Btnl2 impacts γδ TCR...

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Autores principales:	Casandra Panea, Ruoyu Zhang, Jeffrey VanValkenburgh, Min Ni, Christina Adler, Yi Wei, Francisca Ochoa, Jennifer Schmahl, Yajun Tang, Chia-Jen Siao, William Poueymirou, Jennifer Espert, Wei Keat Lim, Gurinder S. Atwal, Andrew J. Murphy, Matthew A. Sleeman, Zaruhi Hovhannisyan, Sokol Haxhinasto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/76b2722c8a4148d38819e67926137016
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spelling	oai:doaj.org-article:76b2722c8a4148d38819e679261370162021-12-02T16:06:36ZButyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes10.1038/s42003-021-02438-x2399-3642https://doaj.org/article/76b2722c8a4148d38819e679261370162021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02438-xhttps://doaj.org/toc/2399-3642Panea et al showed that epithelia-specific butyrophilinlike 2 (Btnl2) suppressed homeostatic proliferation of γδ intraepithelial lymphocytes (IELs) preferentially in the ileum and used high throughput transcriptomic characterization of Btnl2-deficient γδ IELs to demonstrate that Btnl2 impacts γδ TCR specificities and repertoire diversity of ileal γδ IELs. In addition, they showed that Btnl2-deficient mice exhibited increased inflammation and delayed mucosal repair in the colon, suggesting that it plays a key immunological function in intestinal diseases.Casandra PaneaRuoyu ZhangJeffrey VanValkenburghMin NiChristina AdlerYi WeiFrancisca OchoaJennifer SchmahlYajun TangChia-Jen SiaoWilliam PoueymirouJennifer EspertWei Keat LimGurinder S. AtwalAndrew J. MurphyMatthew A. SleemanZaruhi HovhannisyanSokol HaxhinastoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Casandra Panea Ruoyu Zhang Jeffrey VanValkenburgh Min Ni Christina Adler Yi Wei Francisca Ochoa Jennifer Schmahl Yajun Tang Chia-Jen Siao William Poueymirou Jennifer Espert Wei Keat Lim Gurinder S. Atwal Andrew J. Murphy Matthew A. Sleeman Zaruhi Hovhannisyan Sokol Haxhinasto Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
description	Panea et al showed that epithelia-specific butyrophilinlike 2 (Btnl2) suppressed homeostatic proliferation of γδ intraepithelial lymphocytes (IELs) preferentially in the ileum and used high throughput transcriptomic characterization of Btnl2-deficient γδ IELs to demonstrate that Btnl2 impacts γδ TCR specificities and repertoire diversity of ileal γδ IELs. In addition, they showed that Btnl2-deficient mice exhibited increased inflammation and delayed mucosal repair in the colon, suggesting that it plays a key immunological function in intestinal diseases.
format	article
author	Casandra Panea Ruoyu Zhang Jeffrey VanValkenburgh Min Ni Christina Adler Yi Wei Francisca Ochoa Jennifer Schmahl Yajun Tang Chia-Jen Siao William Poueymirou Jennifer Espert Wei Keat Lim Gurinder S. Atwal Andrew J. Murphy Matthew A. Sleeman Zaruhi Hovhannisyan Sokol Haxhinasto
author_facet	Casandra Panea Ruoyu Zhang Jeffrey VanValkenburgh Min Ni Christina Adler Yi Wei Francisca Ochoa Jennifer Schmahl Yajun Tang Chia-Jen Siao William Poueymirou Jennifer Espert Wei Keat Lim Gurinder S. Atwal Andrew J. Murphy Matthew A. Sleeman Zaruhi Hovhannisyan Sokol Haxhinasto
author_sort	Casandra Panea
title	Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
title_short	Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
title_full	Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
title_fullStr	Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
title_full_unstemmed	Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
title_sort	butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/76b2722c8a4148d38819e67926137016
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Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes

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