NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype

NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype

Abstract Atherosclerosis and its consequences cause considerable morbidity and mortality world-wide. We have previously shown that expression of the DNA glycosylase NEIL3 is regulated in human atherosclerotic plaques, and that NEIL3-deficiency enhances atherogenesis in Apoe −/− mice. Herein, we iden...

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Main Authors: Tom Rune Karlsen, Xiang Yi Kong, Sverre Holm, Ana Quiles-Jiménez, Tuva B. Dahl, Kuan Yang, Ellen L. Sagen, Tonje Skarpengland, Jonas D. S. Øgaard, Kristian Holm, Beate Vestad, Maria B. Olsen, Pål Aukrust, Magnar Bjørås, Johannes R. Hov, Bente Halvorsen, Ida Gregersen
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/76e13847e2f34a359ef1a9246eb208b9
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