The origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes
Phosphorothioate (PT) modification by the dnd gene cluster is the first identified DNA backbone modification and has been shown to constitute a multifunctional epigenetic system. Despite a variety of advantages for hosting dnd systems, these systems are surprisingly distributed sporadically among co...
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2021
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oai:doaj.org-article:76e2c0c61900460883a47c6572ee685a2021-11-08T11:08:50ZThe origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes10.1038/s41467-021-26636-72041-1723https://doaj.org/article/76e2c0c61900460883a47c6572ee685a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26636-7https://doaj.org/toc/2041-1723Phosphorothioate (PT) modification by the dnd gene cluster is the first identified DNA backbone modification and has been shown to constitute a multifunctional epigenetic system. Despite a variety of advantages for hosting dnd systems, these systems are surprisingly distributed sporadically among contemporary microbial genomes. To address this ecological paradox, Jian et al. systematically investigated the occurrence and phylogeny of dnd systems in prokaryotes, and provided evidence to suggest that dnd systems have originated in ancient Cyanobacteria (probably Nostocales) after the Great Oxygenation Event.Huahua JianGuanpeng XuYi YiYali HaoYinzhao WangLei XiongSiyuan WangShunzhang LiuCanxing MengJiahua WangYue ZhangChao ChenXiaoyuan FengHaiwei LuoHao ZhangXingguo ZhangLianrong WangZhijun WangZixin DengXiang XiaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
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DOAJ |
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Science Q |
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Science Q Huahua Jian Guanpeng Xu Yi Yi Yali Hao Yinzhao Wang Lei Xiong Siyuan Wang Shunzhang Liu Canxing Meng Jiahua Wang Yue Zhang Chao Chen Xiaoyuan Feng Haiwei Luo Hao Zhang Xingguo Zhang Lianrong Wang Zhijun Wang Zixin Deng Xiang Xiao The origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes |
| description |
Phosphorothioate (PT) modification by the dnd gene cluster is the first identified DNA backbone modification and has been shown to constitute a multifunctional epigenetic system. Despite a variety of advantages for hosting dnd systems, these systems are surprisingly distributed sporadically among contemporary microbial genomes. To address this ecological paradox, Jian et al. systematically investigated the occurrence and phylogeny of dnd systems in prokaryotes, and provided evidence to suggest that dnd systems have originated in ancient Cyanobacteria (probably Nostocales) after the Great Oxygenation Event. |
| format |
article |
| author |
Huahua Jian Guanpeng Xu Yi Yi Yali Hao Yinzhao Wang Lei Xiong Siyuan Wang Shunzhang Liu Canxing Meng Jiahua Wang Yue Zhang Chao Chen Xiaoyuan Feng Haiwei Luo Hao Zhang Xingguo Zhang Lianrong Wang Zhijun Wang Zixin Deng Xiang Xiao |
| author_facet |
Huahua Jian Guanpeng Xu Yi Yi Yali Hao Yinzhao Wang Lei Xiong Siyuan Wang Shunzhang Liu Canxing Meng Jiahua Wang Yue Zhang Chao Chen Xiaoyuan Feng Haiwei Luo Hao Zhang Xingguo Zhang Lianrong Wang Zhijun Wang Zixin Deng Xiang Xiao |
| author_sort |
Huahua Jian |
| title |
The origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes |
| title_short |
The origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes |
| title_full |
The origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes |
| title_fullStr |
The origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes |
| title_full_unstemmed |
The origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes |
| title_sort |
origin and impeded dissemination of the dna phosphorothioation system in prokaryotes |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/76e2c0c61900460883a47c6572ee685a |
| work_keys_str_mv |
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