Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

Aspartate transcarbamoylase acts in de novo pyrimidine biosynthesis and in plants is regulated by feedback inhibition via uridine 5-monophosphate (UMP). Here Bellin et al. describe the structural basis for this feedback inhibition, showing that UMP blocks the active site by binding to a plant specif...

Full description

Saved in:
Bibliographic Details
Main Authors: Leo Bellin, Francisco Del Caño-Ochoa, Adrián Velázquez-Campoy, Torsten Möhlmann, Santiago Ramón-Maiques
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Q
Online Access:https://doaj.org/article/770689c4d26f4402950ea9d01077e796
Tags: Add Tag
No Tags, Be the first to tag this record!