Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

Aspartate transcarbamoylase acts in de novo pyrimidine biosynthesis and in plants is regulated by feedback inhibition via uridine 5-monophosphate (UMP). Here Bellin et al. describe the structural basis for this feedback inhibition, showing that UMP blocks the active site by binding to a plant specif...

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Autores principales:	Leo Bellin, Francisco Del Caño-Ochoa, Adrián Velázquez-Campoy, Torsten Möhlmann, Santiago Ramón-Maiques
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/770689c4d26f4402950ea9d01077e796
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spelling	oai:doaj.org-article:770689c4d26f4402950ea9d01077e7962021-12-02T14:26:44ZMechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase10.1038/s41467-021-21165-92041-1723https://doaj.org/article/770689c4d26f4402950ea9d01077e7962021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21165-9https://doaj.org/toc/2041-1723Aspartate transcarbamoylase acts in de novo pyrimidine biosynthesis and in plants is regulated by feedback inhibition via uridine 5-monophosphate (UMP). Here Bellin et al. describe the structural basis for this feedback inhibition, showing that UMP blocks the active site by binding to a plant specific UMP recognition loop.Leo BellinFrancisco Del Caño-OchoaAdrián Velázquez-CampoyTorsten MöhlmannSantiago Ramón-MaiquesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leo Bellin Francisco Del Caño-Ochoa Adrián Velázquez-Campoy Torsten Möhlmann Santiago Ramón-Maiques Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
description	Aspartate transcarbamoylase acts in de novo pyrimidine biosynthesis and in plants is regulated by feedback inhibition via uridine 5-monophosphate (UMP). Here Bellin et al. describe the structural basis for this feedback inhibition, showing that UMP blocks the active site by binding to a plant specific UMP recognition loop.
format	article
author	Leo Bellin Francisco Del Caño-Ochoa Adrián Velázquez-Campoy Torsten Möhlmann Santiago Ramón-Maiques
author_facet	Leo Bellin Francisco Del Caño-Ochoa Adrián Velázquez-Campoy Torsten Möhlmann Santiago Ramón-Maiques
author_sort	Leo Bellin
title	Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
title_short	Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
title_full	Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
title_fullStr	Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
title_full_unstemmed	Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
title_sort	mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/770689c4d26f4402950ea9d01077e796
work_keys_str_mv	AT leobellin mechanismsoffeedbackinhibitionandsequentialfiringofactivesitesinplantaspartatetranscarbamoylase AT franciscodelcanoochoa mechanismsoffeedbackinhibitionandsequentialfiringofactivesitesinplantaspartatetranscarbamoylase AT adrianvelazquezcampoy mechanismsoffeedbackinhibitionandsequentialfiringofactivesitesinplantaspartatetranscarbamoylase AT torstenmohlmann mechanismsoffeedbackinhibitionandsequentialfiringofactivesitesinplantaspartatetranscarbamoylase AT santiagoramonmaiques mechanismsoffeedbackinhibitionandsequentialfiringofactivesitesinplantaspartatetranscarbamoylase
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Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

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