Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy

ABSTRACT Group A streptococcus (GAS) is an important human pathogen which can cause fatal diseases after invasion into the bloodstream. Although antibiotics and immune surveillance are the main defenses against GAS infection, GAS utilizes internalization into cells as a major immune evasion strategy...

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Main Authors: Yi-Lin Cheng, Chih-Feng Kuo, Shiou-Ling Lu, Hiroko Omori, Ya-Na Wu, Cheng-Lu Hsieh, Takeshi Noda, Shang-Rung Wu, Robert Anderson, Chiou-Feng Lin, Chia-Ling Chen, Jiunn-Jong Wu, Yee-Shin Lin
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
group A streptococcus
LC3-associated phagocytosis (LAP)
xenophagy
reactive oxygen species (ROS)
endothelial cells
Microbiology
QR1-502
Online Access:https://doaj.org/article/7718a4462d4c4695b108a7e8c2b5ef22
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https://doaj.org/article/7718a4462d4c4695b108a7e8c2b5ef22

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