Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein

Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein

The neuropathological hallmarks of Alzheimer’s disease (AD) are senile plaques (SPs), which are composed of amyloid β protein (Aβ), and neurofibrillary tangles (NFTs), which consist of highly phosphorylated tau protein. As bio-metal imbalance may be involved in the formation of NFT and SPs, metal re...

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Detalles Bibliográficos
Autores principales: Gaoping Lin, Feiyan Zhu, Nicholas M. Kanaan, Rei Asano, Norimichi Shirafuji, Hirohito Sasaki, Tomohisa Yamaguchi, Soichi Enomoto, Yoshinori Endo, Asako Ueno, Masamichi Ikawa, Kouji Hayashi, Osamu Yamamura, Shu-Hui Yen, Yasunari Nakamoto, Tadanori Hamano
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
Alzheimer’s disease
clioquinol
tau protein
tau oligomer
JNK
PP2A
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/772bb6631d544c91a2e45d58ccfa195e
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https://doaj.org/article/772bb6631d544c91a2e45d58ccfa195e

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