Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
The human DNA primase and DNA polymerase PrimPol replicates through the major oxidative DNA damage lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis in a mostly error-free manner thus suppressing oxoG-induced mutagenesis in mitochondria and the nucleus. Here, the authors present cryst...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/773f625abe814094998cc661e3a4cdba |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|