Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase

The human DNA primase and DNA polymerase PrimPol replicates through the major oxidative DNA damage lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis in a mostly error-free manner thus suppressing oxoG-induced mutagenesis in mitochondria and the nucleus. Here, the authors present cryst...

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Autores principales:	Olga Rechkoblit, Robert E. Johnson, Yogesh K. Gupta, Louise Prakash, Satya Prakash, Aneel K. Aggarwal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/773f625abe814094998cc661e3a4cdba
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spelling	oai:doaj.org-article:773f625abe814094998cc661e3a4cdba2021-12-02T14:34:06ZStructural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase10.1038/s41467-021-24317-z2041-1723https://doaj.org/article/773f625abe814094998cc661e3a4cdba2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24317-zhttps://doaj.org/toc/2041-1723The human DNA primase and DNA polymerase PrimPol replicates through the major oxidative DNA damage lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis in a mostly error-free manner thus suppressing oxoG-induced mutagenesis in mitochondria and the nucleus. Here, the authors present crystal structures of PrimPol in complex with an oxoG lesion in different contexts that provide mechanistic insights into how PrimPol performs predominantly accurate synthesis on oxidative-damaged DNAs in human cells.Olga RechkoblitRobert E. JohnsonYogesh K. GuptaLouise PrakashSatya PrakashAneel K. AggarwalNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olga Rechkoblit Robert E. Johnson Yogesh K. Gupta Louise Prakash Satya Prakash Aneel K. Aggarwal Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
description	The human DNA primase and DNA polymerase PrimPol replicates through the major oxidative DNA damage lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis in a mostly error-free manner thus suppressing oxoG-induced mutagenesis in mitochondria and the nucleus. Here, the authors present crystal structures of PrimPol in complex with an oxoG lesion in different contexts that provide mechanistic insights into how PrimPol performs predominantly accurate synthesis on oxidative-damaged DNAs in human cells.
format	article
author	Olga Rechkoblit Robert E. Johnson Yogesh K. Gupta Louise Prakash Satya Prakash Aneel K. Aggarwal
author_facet	Olga Rechkoblit Robert E. Johnson Yogesh K. Gupta Louise Prakash Satya Prakash Aneel K. Aggarwal
author_sort	Olga Rechkoblit
title	Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
title_short	Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
title_full	Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
title_fullStr	Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
title_full_unstemmed	Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
title_sort	structural basis of dna synthesis opposite 8-oxoguanine by human primpol primase-polymerase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/773f625abe814094998cc661e3a4cdba
work_keys_str_mv	AT olgarechkoblit structuralbasisofdnasynthesisopposite8oxoguaninebyhumanprimpolprimasepolymerase AT robertejohnson structuralbasisofdnasynthesisopposite8oxoguaninebyhumanprimpolprimasepolymerase AT yogeshkgupta structuralbasisofdnasynthesisopposite8oxoguaninebyhumanprimpolprimasepolymerase AT louiseprakash structuralbasisofdnasynthesisopposite8oxoguaninebyhumanprimpolprimasepolymerase AT satyaprakash structuralbasisofdnasynthesisopposite8oxoguaninebyhumanprimpolprimasepolymerase AT aneelkaggarwal structuralbasisofdnasynthesisopposite8oxoguaninebyhumanprimpolprimasepolymerase
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Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase

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