The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis

The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis

Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is involved in multiple biological functions in cell development, differentiation, and transcriptional regulation. Tet1 deficient mice display the defects of murine glucose metabolism. However, the role of TET1 in metabolic homeostasis kee...

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Main Authors: Chunbo Zhang, Tianyu Zhong, Yuanyuan Li, Xianfeng Li, Xiaopeng Yuan, Linlin Liu, Weilin Wu, Jing Wu, Ye Wu, Rui Liang, Xinhua Xie, Chuanchuan Kang, Yuwen Liu, Zhonghong Lai, Jianbo Xiao, Zhixian Tang, Riqun Jin, Yan Wang, Yongwei Xiao, Jin Zhang, Jian Li, Qian Liu, Zhongsheng Sun, Jianing Zhong
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
TET1
SIRT1
acetylation modification
transcriptional regulation
glucose metabolism
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/774d46896e9b4a30b917a9ad9a0cec1d
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https://doaj.org/article/774d46896e9b4a30b917a9ad9a0cec1d

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