ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus, ZRANB3, that is specific for this population.

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Auteurs principaux: Adebowale A. Adeyemo, Norann A. Zaghloul, Guanjie Chen, Ayo P. Doumatey, Carmen C. Leitch, Timothy L. Hostelley, Jessica E. Nesmith, Jie Zhou, Amy R. Bentley, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Settara Chandrasekharappa, Jokotade Adeleye, William Balogun, Samuel Owusu, Albert Amoah, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement Adebamowo, South Africa Zulu Type 2 Diabetes Case-Control Study, Francis Collins, Georgia Dunston, Charles N. Rotimi
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/7757796c1cc14b99b37e09335d62edfc
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