Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation.

Previous studies have shown that exogenous ATP (>1 µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent mechanism (hydrolysis of ATP to produce the minera...

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Autores principales: Isabel R Orriss, Michelle L Key, Mark O R Hajjawi, Timothy R Arnett
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/777578988f9745a3954f8f5e6e2a260d
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