Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

De novo protein synthesis is required for synapse modifications underlying stable memory encoding. Yet neurons are highly compartmentalized cells and how protein synthesis can be regulated at the synapse level is unknown. Here, we characterize neuronal signaling complexes formed by the postsynaptic...

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Bibliographic Details
Main Authors: María J Conde-Dusman, Partha N Dey, Óscar Elía-Zudaire, Luis G Rabaneda, Carmen García-Lira, Teddy Grand, Victor Briz, Eric R Velasco, Raül Andero, Sergio Niñerola, Angel Barco, Pierre Paoletti, John F Wesseling, Fabrizio Gardoni, Steven J Tavalin, Isabel Perez-Otaño
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
GluN3A
NMDA receptor
mTOR
protein synthesis
memory
GIT1
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/77ce7ee1a4f040119c91bf9ba1582051
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https://doaj.org/article/77ce7ee1a4f040119c91bf9ba1582051

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