Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors

Factors controlling release of loaded cargo from polycationic gene delivery vectors are still poorly understood. Here, the authors report on a study of mechanisms of RNA release, highlighting the role of competitive binding, and characterise the interactome associated with vectors upon cytosolic ent...

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Bibliographic Details
Main Authors: Aji Alex M. Raynold, Danyang Li, Lan Chang, Julien E. Gautrot
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/77e09c05fccf4710b25bf87fca6c7bd8
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