Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors

Factors controlling release of loaded cargo from polycationic gene delivery vectors are still poorly understood. Here, the authors report on a study of mechanisms of RNA release, highlighting the role of competitive binding, and characterise the interactome associated with vectors upon cytosolic ent...

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Autores principales:	Aji Alex M. Raynold, Danyang Li, Lan Chang, Julien E. Gautrot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/77e09c05fccf4710b25bf87fca6c7bd8
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spelling	oai:doaj.org-article:77e09c05fccf4710b25bf87fca6c7bd82021-11-14T12:34:16ZCompetitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors10.1038/s41467-021-26695-w2041-1723https://doaj.org/article/77e09c05fccf4710b25bf87fca6c7bd82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26695-whttps://doaj.org/toc/2041-1723Factors controlling release of loaded cargo from polycationic gene delivery vectors are still poorly understood. Here, the authors report on a study of mechanisms of RNA release, highlighting the role of competitive binding, and characterise the interactome associated with vectors upon cytosolic entry.Aji Alex M. RaynoldDanyang LiLan ChangJulien E. GautrotNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aji Alex M. Raynold Danyang Li Lan Chang Julien E. Gautrot Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
description	Factors controlling release of loaded cargo from polycationic gene delivery vectors are still poorly understood. Here, the authors report on a study of mechanisms of RNA release, highlighting the role of competitive binding, and characterise the interactome associated with vectors upon cytosolic entry.
format	article
author	Aji Alex M. Raynold Danyang Li Lan Chang Julien E. Gautrot
author_facet	Aji Alex M. Raynold Danyang Li Lan Chang Julien E. Gautrot
author_sort	Aji Alex M. Raynold
title	Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
title_short	Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
title_full	Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
title_fullStr	Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
title_full_unstemmed	Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
title_sort	competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/77e09c05fccf4710b25bf87fca6c7bd8
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Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors

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