Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis

Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto-inhibition has therapeutic potential to prevent a...

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Autores principales: Jing-Jing Wang, Fan Liu, Fan Yang, Yi-Zhi Wang, Xin Qi, Ying Li, Qin Hu, Michael X. Zhu, Tian-Le Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/78094fa965a044138ca3cf8dbe009d21
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