Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis

Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto-inhibition has therapeutic potential to prevent a...

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Autores principales:	Jing-Jing Wang, Fan Liu, Fan Yang, Yi-Zhi Wang, Xin Qi, Ying Li, Qin Hu, Michael X. Zhu, Tian-Le Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78094fa965a044138ca3cf8dbe009d21
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spelling	oai:doaj.org-article:78094fa965a044138ca3cf8dbe009d212021-12-02T14:42:14ZDisruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis10.1038/s41467-019-13873-02041-1723https://doaj.org/article/78094fa965a044138ca3cf8dbe009d212020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13873-0https://doaj.org/toc/2041-1723Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto-inhibition has therapeutic potential to prevent acidotoxicity.Jing-Jing WangFan LiuFan YangYi-Zhi WangXin QiYing LiQin HuMichael X. ZhuTian-Le XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing-Jing Wang Fan Liu Fan Yang Yi-Zhi Wang Xin Qi Ying Li Qin Hu Michael X. Zhu Tian-Le Xu Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis
description	Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto-inhibition has therapeutic potential to prevent acidotoxicity.
format	article
author	Jing-Jing Wang Fan Liu Fan Yang Yi-Zhi Wang Xin Qi Ying Li Qin Hu Michael X. Zhu Tian-Le Xu
author_facet	Jing-Jing Wang Fan Liu Fan Yang Yi-Zhi Wang Xin Qi Ying Li Qin Hu Michael X. Zhu Tian-Le Xu
author_sort	Jing-Jing Wang
title	Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis
title_short	Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis
title_full	Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis
title_fullStr	Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis
title_full_unstemmed	Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis
title_sort	disruption of auto-inhibition underlies conformational signaling of asic1a to induce neuronal necroptosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/78094fa965a044138ca3cf8dbe009d21
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Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis

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