Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 ± 20 nm, a polydispersity index of 0.238 ± 0.001, a zeta potential of +19...

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Main Authors: Rafaela Figueiredo Rodrigues, Juliana Barbosa Nunes, Sandra Barbosa Neder Agostini, Paloma Freitas dos Santos, Juliana Cancino-Bernardi, Rodrigo Vicentino Placido, Thamyris Reis Moraes, Jennifer Tavares Jacon Freitas, Gislaine Ribeiro Pereira, Flávia Chiva Carvalho, Giovane Galdino, Vanessa Bergamin Boralli
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
neuropathy
polymeric nanoparticles
preclinical investigation
pharmacokinetics of pregabalin
antinociceptive effect
induced sleep
Organic chemistry
QD241-441
Online Access:https://doaj.org/article/7829cca9daee4d8e95b7582b1cae90af
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https://doaj.org/article/7829cca9daee4d8e95b7582b1cae90af

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