Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 ± 20 nm, a polydispersity index of 0.238 ± 0.001, a zeta potential of +19...

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Auteurs principaux:	Rafaela Figueiredo Rodrigues, Juliana Barbosa Nunes, Sandra Barbosa Neder Agostini, Paloma Freitas dos Santos, Juliana Cancino-Bernardi, Rodrigo Vicentino Placido, Thamyris Reis Moraes, Jennifer Tavares Jacon Freitas, Gislaine Ribeiro Pereira, Flávia Chiva Carvalho, Giovane Galdino, Vanessa Bergamin Boralli
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	neuropathy polymeric nanoparticles preclinical investigation pharmacokinetics of pregabalin antinociceptive effect induced sleep Organic chemistry QD241-441
Accès en ligne:	https://doaj.org/article/7829cca9daee4d8e95b7582b1cae90af
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Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

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