Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.

The Karyopherin superfamily comprises nuclear transport proteins, involved in the shuttling of certain cargo proteins into and out of the nucleus. Karyopherin β1 (Kpnβ1) and Karyopherin α2 (Kpnα2) are importin proteins, which work in concert to transport their cargo into the nucleus. We previously i...

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Autores principales: Pauline J van der Watt, Ellen Ngarande, Virna D Leaner
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/782f73de7e1240b2a9311308a8d8b738
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