Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination

Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination

Alternative end joining (A-EJ) catalyzes substantial level of antibody class switch recombination (CSR) in B cells deficient for classical non-homologous end joining, featuring increased switch (S) region DSB resection and junctional microhomology (MH). While resection has been suggested to initiate...

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Bibliographic Details
Main Authors: Xikui Sun, Jingning Bai, Jiejie Xu, Xiaoli Xi, Mingyu Gu, Chengming Zhu, Hongman Xue, Chun Chen, Junchao Dong
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
DNA double-strand breaks repair
alternative end joining
class switch recombination
DSB end resection
microhomology
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/783e94bec6534c0ba59ab903e0bf080f
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https://doaj.org/article/783e94bec6534c0ba59ab903e0bf080f

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