Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam, Avinash Bhandoola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/784327815c984356aac217a9fbd2ed1e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:784327815c984356aac217a9fbd2ed1e
record_format	dspace
spelling	oai:doaj.org-article:784327815c984356aac217a9fbd2ed1e2021-12-02T14:39:58ZMyc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth10.1038/s41467-019-13465-y2041-1723https://doaj.org/article/784327815c984356aac217a9fbd2ed1e2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13465-yhttps://doaj.org/toc/2041-1723Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in thymus size, and thereby expedited T cell generation.Jennifer E. CowanJustin MalinYongge ZhaoMina O. SeedhomChristelle HarlyIzumi OhigashiMichael KellyYousuke TakahamaJonathan W. YewdellMaggie CamAvinash BhandoolaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer E. Cowan Justin Malin Yongge Zhao Mina O. Seedhom Christelle Harly Izumi Ohigashi Michael Kelly Yousuke Takahama Jonathan W. Yewdell Maggie Cam Avinash Bhandoola Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
description	Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in thymus size, and thereby expedited T cell generation.
format	article
author	Jennifer E. Cowan Justin Malin Yongge Zhao Mina O. Seedhom Christelle Harly Izumi Ohigashi Michael Kelly Yousuke Takahama Jonathan W. Yewdell Maggie Cam Avinash Bhandoola
author_facet	Jennifer E. Cowan Justin Malin Yongge Zhao Mina O. Seedhom Christelle Harly Izumi Ohigashi Michael Kelly Yousuke Takahama Jonathan W. Yewdell Maggie Cam Avinash Bhandoola
author_sort	Jennifer E. Cowan
title	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_short	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_full	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_fullStr	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_full_unstemmed	Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
title_sort	myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/784327815c984356aac217a9fbd2ed1e
work_keys_str_mv	AT jenniferecowan myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT justinmalin myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT yonggezhao myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT minaoseedhom myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT christelleharly myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT izumiohigashi myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT michaelkelly myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT yousuketakahama myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT jonathanwyewdell myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT maggiecam myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth AT avinashbhandoola myccontrolsadistincttranscriptionalprograminfetalthymicepithelialcellsthatdeterminesthymusgrowth
_version_	1718390424342626304

Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Ejemplares similares