DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis

DNA polymerase epsilon (Pol ε) synthesizes half of the genome in every cell cycle. Here the authors uncover a dual role of a unique domain within the Pol ε catalytic core in replisome assembly and DNA synthesis and the impact of this domain on genome stability.

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Autores principales: Xiangzhou Meng, Lei Wei, Sujan Devbhandari, Tuo Zhang, Jenny Xiang, Dirk Remus, Xiaolan Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/784f3f5d0e034b3d9506e9710237067b
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