DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis

DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis

DNA polymerase epsilon (Pol ε) synthesizes half of the genome in every cell cycle. Here the authors uncover a dual role of a unique domain within the Pol ε catalytic core in replisome assembly and DNA synthesis and the impact of this domain on genome stability.

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Autores principales: Xiangzhou Meng, Lei Wei, Sujan Devbhandari, Tuo Zhang, Jenny Xiang, Dirk Remus, Xiaolan Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/784f3f5d0e034b3d9506e9710237067b
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spelling oai:doaj.org-article:784f3f5d0e034b3d9506e9710237067b2021-12-02T15:54:49ZDNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis10.1038/s41467-020-16095-x2041-1723https://doaj.org/article/784f3f5d0e034b3d9506e9710237067b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16095-xhttps://doaj.org/toc/2041-1723DNA polymerase epsilon (Pol ε) synthesizes half of the genome in every cell cycle. Here the authors uncover a dual role of a unique domain within the Pol ε catalytic core in replisome assembly and DNA synthesis and the impact of this domain on genome stability.Xiangzhou MengLei WeiSujan DevbhandariTuo ZhangJenny XiangDirk RemusXiaolan ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiangzhou Meng
Lei Wei
Sujan Devbhandari
Tuo Zhang
Jenny Xiang
Dirk Remus
Xiaolan Zhao
DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
description DNA polymerase epsilon (Pol ε) synthesizes half of the genome in every cell cycle. Here the authors uncover a dual role of a unique domain within the Pol ε catalytic core in replisome assembly and DNA synthesis and the impact of this domain on genome stability.
format article
author Xiangzhou Meng
Lei Wei
Sujan Devbhandari
Tuo Zhang
Jenny Xiang
Dirk Remus
Xiaolan Zhao
author_facet Xiangzhou Meng
Lei Wei
Sujan Devbhandari
Tuo Zhang
Jenny Xiang
Dirk Remus
Xiaolan Zhao
author_sort Xiangzhou Meng
title DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
title_short DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
title_full DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
title_fullStr DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
title_full_unstemmed DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
title_sort dna polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/784f3f5d0e034b3d9506e9710237067b
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