The CaMKII holoenzyme structure in activation-competent conformations

The CaMKII holoenzyme structure in activation-competent conformations

Ca2+/calmodulin-dependent protein kinase II (CaMKII) forms a 12 subunit holoenzyme central to synaptic plasticity. Here the authors report a 3D structure of the CaMKII holoenzyme in an activation-competent state obtained by single particle EM, and suggest a role for the intrinsically disordered link...

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Bibliographic Details
Main Authors: Janette B. Myers, Vincent Zaegel, Steven J. Coultrap, Adam P. Miller, K. Ulrich Bayer, Steve L. Reichow
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/7852f7f279904d55b15ee9e82bae8fc7
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