Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice.

Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the rectum which progressively extents. Its etiology remains unknown and the number of treatments available is limited. Studies of UC patients have identified an unbalanced endoplasmic reticulum (ER) stress in the non-inflamed...

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Main Authors: Xavier Tréton, Eric Pedruzzi, Cécile Guichard, Yannick Ladeiro, Shirin Sedghi, Mélissa Vallée, Neike Fernandez, Emilie Bruyère, Paul-Louis Woerther, Robert Ducroc, Nicolas Montcuquet, Jean-Noel Freund, Isabelle Van Seuningen, Frédérick Barreau, Assiya Marah, Jean-Pierre Hugot, Dominique Cazals-Hatem, Yoram Bouhnik, Fanny Daniel, Eric Ogier-Denis
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/785d897e7a834d739ab99c7e3081bc4c
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