CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition

CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips of the T cell microvilli and that this occurs p...

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Autores principales: Yunmin Jung, Lai Wen, Amnon Altman, Klaus Ley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7868c43b5a2049ff80ee50c8d4276381
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