CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition

CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips of the T cell microvilli and that this occurs p...

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Autores principales:	Yunmin Jung, Lai Wen, Amnon Altman, Klaus Ley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7868c43b5a2049ff80ee50c8d4276381
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spelling	oai:doaj.org-article:7868c43b5a2049ff80ee50c8d42763812021-12-02T17:44:52ZCD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition10.1038/s41467-021-23792-82041-1723https://doaj.org/article/7868c43b5a2049ff80ee50c8d42763812021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23792-8https://doaj.org/toc/2041-1723CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips of the T cell microvilli and that this occurs prior to contact with antigen, indicating this exclusion is one of the initiating factors for antigen presentation and T cell activation.Yunmin JungLai WenAmnon AltmanKlaus LeyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunmin Jung Lai Wen Amnon Altman Klaus Ley CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
description	CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the tips of the T cell microvilli and that this occurs prior to contact with antigen, indicating this exclusion is one of the initiating factors for antigen presentation and T cell activation.
format	article
author	Yunmin Jung Lai Wen Amnon Altman Klaus Ley
author_facet	Yunmin Jung Lai Wen Amnon Altman Klaus Ley
author_sort	Yunmin Jung
title	CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
title_short	CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
title_full	CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
title_fullStr	CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
title_full_unstemmed	CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition
title_sort	cd45 pre-exclusion from the tips of t cell microvilli prior to antigen recognition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7868c43b5a2049ff80ee50c8d4276381
work_keys_str_mv	AT yunminjung cd45preexclusionfromthetipsoftcellmicrovillipriortoantigenrecognition AT laiwen cd45preexclusionfromthetipsoftcellmicrovillipriortoantigenrecognition AT amnonaltman cd45preexclusionfromthetipsoftcellmicrovillipriortoantigenrecognition AT klausley cd45preexclusionfromthetipsoftcellmicrovillipriortoantigenrecognition
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CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition

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