Caffeine-inducible gene switches controlling experimental diabetes

Control of transgene expression should ideally be easy and with minimal side effects. Here the authors present a synthetic biology-based approach in which the caffeine in coffee regulates a genetic circuit controlling glucagon-like peptide 1 expression in diabetic mice.

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Autores principales:	Daniel Bojar, Leo Scheller, Ghislaine Charpin-El Hamri, Mingqi Xie, Martin Fussenegger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78897e8e6b274e48b9f08daab11ccd6a
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spelling	oai:doaj.org-article:78897e8e6b274e48b9f08daab11ccd6a2021-12-02T16:50:06ZCaffeine-inducible gene switches controlling experimental diabetes10.1038/s41467-018-04744-12041-1723https://doaj.org/article/78897e8e6b274e48b9f08daab11ccd6a2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04744-1https://doaj.org/toc/2041-1723Control of transgene expression should ideally be easy and with minimal side effects. Here the authors present a synthetic biology-based approach in which the caffeine in coffee regulates a genetic circuit controlling glucagon-like peptide 1 expression in diabetic mice.Daniel BojarLeo SchellerGhislaine Charpin-El HamriMingqi XieMartin FusseneggerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Bojar Leo Scheller Ghislaine Charpin-El Hamri Mingqi Xie Martin Fussenegger Caffeine-inducible gene switches controlling experimental diabetes
description	Control of transgene expression should ideally be easy and with minimal side effects. Here the authors present a synthetic biology-based approach in which the caffeine in coffee regulates a genetic circuit controlling glucagon-like peptide 1 expression in diabetic mice.
format	article
author	Daniel Bojar Leo Scheller Ghislaine Charpin-El Hamri Mingqi Xie Martin Fussenegger
author_facet	Daniel Bojar Leo Scheller Ghislaine Charpin-El Hamri Mingqi Xie Martin Fussenegger
author_sort	Daniel Bojar
title	Caffeine-inducible gene switches controlling experimental diabetes
title_short	Caffeine-inducible gene switches controlling experimental diabetes
title_full	Caffeine-inducible gene switches controlling experimental diabetes
title_fullStr	Caffeine-inducible gene switches controlling experimental diabetes
title_full_unstemmed	Caffeine-inducible gene switches controlling experimental diabetes
title_sort	caffeine-inducible gene switches controlling experimental diabetes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/78897e8e6b274e48b9f08daab11ccd6a
work_keys_str_mv	AT danielbojar caffeineinduciblegeneswitchescontrollingexperimentaldiabetes AT leoscheller caffeineinduciblegeneswitchescontrollingexperimentaldiabetes AT ghislainecharpinelhamri caffeineinduciblegeneswitchescontrollingexperimentaldiabetes AT mingqixie caffeineinduciblegeneswitchescontrollingexperimentaldiabetes AT martinfussenegger caffeineinduciblegeneswitchescontrollingexperimentaldiabetes
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Caffeine-inducible gene switches controlling experimental diabetes

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