Structural basis for the biosynthesis of lovastatin

Biosynthesis of the statin precursor lovastatin depends on the LovB–LovC megasynthase complex. Here, the authors present cryoEM structures of LovB–LovC and core LovB, providing structural insights into the catalytic cycle underlying lovastatin production.

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Detalles Bibliográficos
Autores principales:	Jialiang Wang, Jingdan Liang, Lu Chen, Wei Zhang, Liangliang Kong, Chao Peng, Chen Su, Yi Tang, Zixin Deng, Zhijun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78a7ab70c6d545e6b1e3702fbf340601
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spelling	oai:doaj.org-article:78a7ab70c6d545e6b1e3702fbf3406012021-12-02T14:26:44ZStructural basis for the biosynthesis of lovastatin10.1038/s41467-021-21174-82041-1723https://doaj.org/article/78a7ab70c6d545e6b1e3702fbf3406012021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21174-8https://doaj.org/toc/2041-1723Biosynthesis of the statin precursor lovastatin depends on the LovB–LovC megasynthase complex. Here, the authors present cryoEM structures of LovB–LovC and core LovB, providing structural insights into the catalytic cycle underlying lovastatin production.Jialiang WangJingdan LiangLu ChenWei ZhangLiangliang KongChao PengChen SuYi TangZixin DengZhijun WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jialiang Wang Jingdan Liang Lu Chen Wei Zhang Liangliang Kong Chao Peng Chen Su Yi Tang Zixin Deng Zhijun Wang Structural basis for the biosynthesis of lovastatin
description	Biosynthesis of the statin precursor lovastatin depends on the LovB–LovC megasynthase complex. Here, the authors present cryoEM structures of LovB–LovC and core LovB, providing structural insights into the catalytic cycle underlying lovastatin production.
format	article
author	Jialiang Wang Jingdan Liang Lu Chen Wei Zhang Liangliang Kong Chao Peng Chen Su Yi Tang Zixin Deng Zhijun Wang
author_facet	Jialiang Wang Jingdan Liang Lu Chen Wei Zhang Liangliang Kong Chao Peng Chen Su Yi Tang Zixin Deng Zhijun Wang
author_sort	Jialiang Wang
title	Structural basis for the biosynthesis of lovastatin
title_short	Structural basis for the biosynthesis of lovastatin
title_full	Structural basis for the biosynthesis of lovastatin
title_fullStr	Structural basis for the biosynthesis of lovastatin
title_full_unstemmed	Structural basis for the biosynthesis of lovastatin
title_sort	structural basis for the biosynthesis of lovastatin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/78a7ab70c6d545e6b1e3702fbf340601
work_keys_str_mv	AT jialiangwang structuralbasisforthebiosynthesisoflovastatin AT jingdanliang structuralbasisforthebiosynthesisoflovastatin AT luchen structuralbasisforthebiosynthesisoflovastatin AT weizhang structuralbasisforthebiosynthesisoflovastatin AT liangliangkong structuralbasisforthebiosynthesisoflovastatin AT chaopeng structuralbasisforthebiosynthesisoflovastatin AT chensu structuralbasisforthebiosynthesisoflovastatin AT yitang structuralbasisforthebiosynthesisoflovastatin AT zixindeng structuralbasisforthebiosynthesisoflovastatin AT zhijunwang structuralbasisforthebiosynthesisoflovastatin
_version_	1718391319211016192

Structural basis for the biosynthesis of lovastatin

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