Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
The monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal s...
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Main Authors: | Jonathan Dorival, Fanny Risser, Christophe Jacob, Sabrina Collin, Gerald Dräger, Cédric Paris, Benjamin Chagot, Andreas Kirschning, Arnaud Gruez, Kira J. Weissman |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
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Online Access: | https://doaj.org/article/78b38c0a3e20488982c5b94105e162f4 |
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