Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function

Abstract Selective serotonin reuptake inhibitors (SSRIs) bind 5-HT transporters, leading to the accumulation of 5-HT and amelioration of depression. Although different mouse strains show varying sensitivity to SSRIs in mouse models of depression, the underlying mechanism of these strain differences...

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Autores principales: Zeng-liang Jin, Xiao-Fei Chen, Yu-hua Ran, Xiao-rong Li, Jie Xiong, Yuan-yuan Zheng, Na-na Gao, Yun-Feng Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/78bdd53ea6f84db08c81c21dfa765df5
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