Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function

Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function

Abstract Selective serotonin reuptake inhibitors (SSRIs) bind 5-HT transporters, leading to the accumulation of 5-HT and amelioration of depression. Although different mouse strains show varying sensitivity to SSRIs in mouse models of depression, the underlying mechanism of these strain differences...

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Autores principales: Zeng-liang Jin, Xiao-Fei Chen, Yu-hua Ran, Xiao-rong Li, Jie Xiong, Yuan-yuan Zheng, Na-na Gao, Yun-Feng Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/78bdd53ea6f84db08c81c21dfa765df5
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