Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos

Abstract In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops...

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Autores principales: Rosemary H. C. Wilson, Dawn Coverley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/78cd343bfcc845978af6ed6dff350e32
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