Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos

Abstract In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops...

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Autores principales:	Rosemary H. C. Wilson, Dawn Coverley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78cd343bfcc845978af6ed6dff350e32
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spelling	oai:doaj.org-article:78cd343bfcc845978af6ed6dff350e322021-12-02T11:52:57ZTransformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos10.1038/s41598-017-06459-72045-2322https://doaj.org/article/78cd343bfcc845978af6ed6dff350e322017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06459-7https://doaj.org/toc/2045-2322Abstract In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use it to demonstrate that malignant transformation compromises the DNA-nuclear matrix interface.Rosemary H. C. WilsonDawn CoverleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rosemary H. C. Wilson Dawn Coverley Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos
description	Abstract In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use it to demonstrate that malignant transformation compromises the DNA-nuclear matrix interface.
format	article
author	Rosemary H. C. Wilson Dawn Coverley
author_facet	Rosemary H. C. Wilson Dawn Coverley
author_sort	Rosemary H. C. Wilson
title	Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos
title_short	Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos
title_full	Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos
title_fullStr	Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos
title_full_unstemmed	Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos
title_sort	transformation-induced changes in the dna-nuclear matrix interface, revealed by high-throughput analysis of dna halos
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/78cd343bfcc845978af6ed6dff350e32
work_keys_str_mv	AT rosemaryhcwilson transformationinducedchangesinthednanuclearmatrixinterfacerevealedbyhighthroughputanalysisofdnahalos AT dawncoverley transformationinducedchangesinthednanuclearmatrixinterfacerevealedbyhighthroughputanalysisofdnahalos
_version_	1718394934474571776

Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halos

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